Overview
Project Title: Phosphoinositide 3-kinase in pancreatic beta cell function
Supervisor: Tania Maffucci
Co-Supervisor: Marco Falasca
An enthusiastic graduate with an interest in cell biology, biochemistry, signal transduction and with at least an upper second class honours degree is required for this project based at the Centre for Diabetes, located at the Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry (SMD), London, to commence in October 2010.
Diabetes is becoming a worldwide epidemic. Although the primary cause of this disease is still unknown, it has become increasingly evident that defects in the cellular mechanisms regulating pancreatic beta cell growth/survival and function are critical for the onset of the disease.
This project, funded by Diabetes UK, will investigate the intracellular mechanisms regulating pancreatic beta cell function with particular attention to the role of enzymes of the family phosphoinositide 3-kinase (PI3Ks). PI3Ks are key regulators of several cellular processes and it is well established that deregulation of PI3Ks are associated with many disease, including diabetes. This project will determine the contribution of specific PI3K isoforms to regulation of pancreatic beta cell functions (including their potential role in regulation of insulin secretion). The effect of alteration of PI3K-dependent cellular signals on pancreatic beta cells will also be investigated.
The student will interact closely with members of the Centre for Diabetes, especially with members of the Inositide Signalling Group. This studentship will expose the student to variety of in vitro and in vivo experimental techniques and an excellent training environment in both cellular and molecular biology.
Our laboratory is located in the Blizard Institute of Cell and Molecular Science located in Whitechapel, London. Here, the graduate will have access to a wide variety of cutting-edge technologies and core facilities, as well as interaction with researchers across a wide range of biomedical research. In the recent Research Assessment Exercise Institute was ranked joint first for research quality in the UK, and in the RAE overall, Barts and the London was top in London, and 4th in the UK overall.
For an informal discussion, please contact the lead project supervisor:
Tania Maffucci - Email: t.maffucci@qmul.ac.uk
To apply, please download the paper-based School of Medicine & Dentistry application form from our website:
http://www.qmul.ac.uk/postgraduate/apply/index.html
and return to the Admissions Office - email: pgsmd@qmul.ac.uk
Please note that we accept postal and electronic applications.
Referees may email references directly to pgsmd@qmul.ac.uk
Please also email directly the supervisor, attaching a copy of your updated CV and naming 2 academic referees.
This studentship is funded by Diabetes UK and comes with a minimum tax free stipend of £15,500 per annum. This studentship is open to UK Nationals, EEA/Swiss migrant workers and non UK nationals with indefinite leave to remain in the UK who all have three years ordinary residence in the EU prior to the start of the studentship.
Closing date for applications is 9 Apr 2010
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
Project Title: Phosphoinositide 3-kinase in pancreatic beta cell function
Supervisor: Tania Maffucci
Co-Supervisor: Marco Falasca
An enthusiastic graduate with an interest in cell biology, biochemistry, signal transduction and with at least an upper second class honours degree is required for this project based at the Centre for Diabetes, located at the Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry (SMD), London, to commence in October 2010.
Diabetes is becoming a worldwide epidemic. Although the primary cause of this disease is still unknown, it has become increasingly evident that defects in the cellular mechanisms regulating pancreatic beta cell growth/survival and function are critical for the onset of the disease.
This project, funded by Diabetes UK, will investigate the intracellular mechanisms regulating pancreatic beta cell function with particular attention to the role of enzymes of the family phosphoinositide 3-kinase (PI3Ks). PI3Ks are key regulators of several cellular processes and it is well established that deregulation of PI3Ks are associated with many disease, including diabetes. This project will determine the contribution of specific PI3K isoforms to regulation of pancreatic beta cell functions (including their potential role in regulation of insulin secretion). The effect of alteration of PI3K-dependent cellular signals on pancreatic beta cells will also be investigated.
The student will interact closely with members of the Centre for Diabetes, especially with members of the Inositide Signalling Group. This studentship will expose the student to variety of in vitro and in vivo experimental techniques and an excellent training environment in both cellular and molecular biology.
Our laboratory is located in the Blizard Institute of Cell and Molecular Science located in Whitechapel, London. Here, the graduate will have access to a wide variety of cutting-edge technologies and core facilities, as well as interaction with researchers across a wide range of biomedical research. In the recent Research Assessment Exercise Institute was ranked joint first for research quality in the UK, and in the RAE overall, Barts and the London was top in London, and 4th in the UK overall.
For an informal discussion, please contact the lead project supervisor:
Tania Maffucci - Email: t.maffucci@qmul.ac.uk
To apply, please download the paper-based School of Medicine & Dentistry application form from our website:
http://www.qmul.ac.uk/postgraduate/apply/index.html
and return to the Admissions Office - email: pgsmd@qmul.ac.uk
Please note that we accept postal and electronic applications.
Referees may email references directly to pgsmd@qmul.ac.uk
Please also email directly the supervisor, attaching a copy of your updated CV and naming 2 academic referees.
This studentship is funded by Diabetes UK and comes with a minimum tax free stipend of £15,500 per annum. This studentship is open to UK Nationals, EEA/Swiss migrant workers and non UK nationals with indefinite leave to remain in the UK who all have three years ordinary residence in the EU prior to the start of the studentship.
Closing date for applications is 9 Apr 2010
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
2 comments:
hi
This studentship will expose the student to variety of in vitro and in vivo experimental techniques and an excellent training environment in both cellular and molecular biology.
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