Overview
You will work in the field of Molecular Neurobiology (including neurodevelopmental aspects), using (epi)genetic, molecular, cell-biological, physiological and behavioural research approaches. The research will be performed within the context of a TI Pharma project with Lundbeck A/S (Denmark) as industrial partner.
Project in short
A fundamental question in the neurobiology of psychiatric disorders is how the interaction between predisposing genes and a change in environment (e.g. early-life stressors) can produce a phenotype that is vulnerable to a neurodevelopmental disorder, such as schizophrenia. To address this question, a rat model (the behaviourally well-characterized so-called APO-SUS and APO-UNSUS rats) has been developed; APO-SUS rats display deficits also observed in schizophrenia. The main goal is to establish the molecular-genetic and neurobiological basis of the rat model by (i) exploring differences in (epi)genetic make-up and mRNA/(phospho)protein expression profiles, and linking these differences to the behavioural features; (ii) studying how early-life experience modulates the pathways to permanently modify the phenotype; (iii) examining in adulthood how an environmental challenge acts on the susceptibility pathways shaped by the genetic background and early-life experience. In translational research, variations in human genes encoding pathways identified in the rat model will be explored to identify susceptibility genes for psychiatric disorders. Through our studies we hope to highlight the crucial role of neurodevelopmental signalling pathways and stressful (early) life events in programming the brain for vulnerability to neurodevelopmental psychiatric disorders.
Requirements
You should have obtained a PhD degree in Molecular/Cellular Neurobiology, Molecular Life Sciences or equivalent. Preferably, you have a background in Developmental Biology, experience with animal models and a high affinity with fundamental research related to clinical problems. Relevant experience with animal behavioural research is an advantage.
Organization
The challenge of the research performed in the Department of Molecular Animal Physiology (MAP) is to map the brain from genotype to molecular pathways in neurodevelopmental trajectories to neuronal circuitry phenotypes and beyond to behaviour and cognition. MAP is part of the Donders Centre for Neuroscience (DCN)/Donders Institute for Brain, Cognition and Behaviour, and affiliated with and housed in the Nijmegen Centre for Molecular Life Sciences (NCMLS) of Radboud University Nijmegen. MAP research is part of DCN theme 3 (Learning, memory and plasticity, more specifically, neurodevelopment), and NCMLS theme 3 (Cell growth and differentiation, more specifically, (epi)genetic pathways of disease). Website: http://molanphys.ruhosting.nl/
DCN groups combine basic research on cognitive neuroscience (investigating the neuronal processes involved in attention, action, perception, adaptation, neuroplasticity, emotion and language) and applied clinical research (with a focus on diagnosis and therapy, on techniques for use in normal and pathological cognitive dysfunction, and on understanding the pathophysiology and aetiology of psychiatric and neurological syndromes). Website: www.ru.nl/dcn
NCMLS is a leading European research school within the domain of Molecular Mechanisms of Disease, and provides an excellent and challenging research environment. Website: www.ncmls.eu
Radboud University Nijmegen is one of the leading academic communities in the Netherlands and renowned for its green leafy campus, modern buildings, and state-of-the-art equipment. Nijmegen is the oldest city in the Netherlands and has a lively city centre.
Website: http://www.ru.nl/dcn
Conditions of employment
Employment: 1,0 fte
Maximum salary per month, based on a fulltime employment: € 3,755 gross/month
Salary scale: 10
Duration of the contract: One year; with the possibility of extension by two years.
Other Information
Applications should include a cover letter with motivation, a research statement, a curriculum vitae, a list of publications and the names of at least two referees. If you apply by e-mail, please send your application in Word, PDF or TXT format.
Additional Information
prof. dr. G.J.M. Martens; full professor of Zoology
Telephone: +31 (0)24 3610564
E-mail: g.martens@ncmls.ru.nl
Application
You can apply for the job (mention the vacancy number 62.50.09) before 15 January 2010 by sending your application -preferably by email- to:
RU Nijmegen, FNWI, P&O, mrs. M. Coppus
P.O. Box 9010, 6500 GL Nijmegen, NL
Telephone: +31(0) 24 3652250
E-mail: pz@science.ru.nl
Please kindly mention Scholarization.blogspot.com when applying for this scholarship
You will work in the field of Molecular Neurobiology (including neurodevelopmental aspects), using (epi)genetic, molecular, cell-biological, physiological and behavioural research approaches. The research will be performed within the context of a TI Pharma project with Lundbeck A/S (Denmark) as industrial partner.
Project in short
A fundamental question in the neurobiology of psychiatric disorders is how the interaction between predisposing genes and a change in environment (e.g. early-life stressors) can produce a phenotype that is vulnerable to a neurodevelopmental disorder, such as schizophrenia. To address this question, a rat model (the behaviourally well-characterized so-called APO-SUS and APO-UNSUS rats) has been developed; APO-SUS rats display deficits also observed in schizophrenia. The main goal is to establish the molecular-genetic and neurobiological basis of the rat model by (i) exploring differences in (epi)genetic make-up and mRNA/(phospho)protein expression profiles, and linking these differences to the behavioural features; (ii) studying how early-life experience modulates the pathways to permanently modify the phenotype; (iii) examining in adulthood how an environmental challenge acts on the susceptibility pathways shaped by the genetic background and early-life experience. In translational research, variations in human genes encoding pathways identified in the rat model will be explored to identify susceptibility genes for psychiatric disorders. Through our studies we hope to highlight the crucial role of neurodevelopmental signalling pathways and stressful (early) life events in programming the brain for vulnerability to neurodevelopmental psychiatric disorders.
Requirements
You should have obtained a PhD degree in Molecular/Cellular Neurobiology, Molecular Life Sciences or equivalent. Preferably, you have a background in Developmental Biology, experience with animal models and a high affinity with fundamental research related to clinical problems. Relevant experience with animal behavioural research is an advantage.
Organization
The challenge of the research performed in the Department of Molecular Animal Physiology (MAP) is to map the brain from genotype to molecular pathways in neurodevelopmental trajectories to neuronal circuitry phenotypes and beyond to behaviour and cognition. MAP is part of the Donders Centre for Neuroscience (DCN)/Donders Institute for Brain, Cognition and Behaviour, and affiliated with and housed in the Nijmegen Centre for Molecular Life Sciences (NCMLS) of Radboud University Nijmegen. MAP research is part of DCN theme 3 (Learning, memory and plasticity, more specifically, neurodevelopment), and NCMLS theme 3 (Cell growth and differentiation, more specifically, (epi)genetic pathways of disease). Website: http://molanphys.ruhosting.nl/
DCN groups combine basic research on cognitive neuroscience (investigating the neuronal processes involved in attention, action, perception, adaptation, neuroplasticity, emotion and language) and applied clinical research (with a focus on diagnosis and therapy, on techniques for use in normal and pathological cognitive dysfunction, and on understanding the pathophysiology and aetiology of psychiatric and neurological syndromes). Website: www.ru.nl/dcn
NCMLS is a leading European research school within the domain of Molecular Mechanisms of Disease, and provides an excellent and challenging research environment. Website: www.ncmls.eu
Radboud University Nijmegen is one of the leading academic communities in the Netherlands and renowned for its green leafy campus, modern buildings, and state-of-the-art equipment. Nijmegen is the oldest city in the Netherlands and has a lively city centre.
Website: http://www.ru.nl/dcn
Conditions of employment
Employment: 1,0 fte
Maximum salary per month, based on a fulltime employment: € 3,755 gross/month
Salary scale: 10
Duration of the contract: One year; with the possibility of extension by two years.
Other Information
Applications should include a cover letter with motivation, a research statement, a curriculum vitae, a list of publications and the names of at least two referees. If you apply by e-mail, please send your application in Word, PDF or TXT format.
Additional Information
prof. dr. G.J.M. Martens; full professor of Zoology
Telephone: +31 (0)24 3610564
E-mail: g.martens@ncmls.ru.nl
Application
You can apply for the job (mention the vacancy number 62.50.09) before 15 January 2010 by sending your application -preferably by email- to:
RU Nijmegen, FNWI, P&O, mrs. M. Coppus
P.O. Box 9010, 6500 GL Nijmegen, NL
Telephone: +31(0) 24 3652250
E-mail: pz@science.ru.nl
Please kindly mention Scholarization.blogspot.com when applying for this scholarship
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