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Friday, December 31, 2010

Two Postdoctoral Fellows in Environmental Epigenetics

Overview

The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) has been established at the Faculty of Health Sciences, University of Copenhagen, to conduct research into basic metabolic functions. The center which consists of five scientific sections and a number of international research satellites was established through a grant from the Novo Nordisk Foundation. The position is in the section for Integrative Physiology headed by Juleen Zierath in the group for Environmental Epigenetics lead by Romain Barres.

Project Description:

Type 2 Diabetes is growing at pandemic rates worldwide, reflecting a synergic interaction between genetic and environmental factors. Epigenetics refers to heritable states of gene expression that are not due to changes in DNA sequence. Two major epigenetic processes, DNA methylation and histone modifications, form the molecular basis of epigenetics, principally by modulating the access of the transcription machinery to the chromatin. Previously, we showed that environmental factors such as diet participate in the etiology of T2D through epigenetic modifications in somatic tissues. The molecular mechanisms involved are yet to be identified. We are seeking two highly motivated Postdoctoral Fellows with excellent skills in molecular biology, biochemistry and cellular biology, to dissect the molecular mechanisms involved in nutrient and exercise-induced epigenetic modifications in metabolic tissues.

The project includes a range of nucleic acid related techniques (DNA and RNA extraction, miRNA cloning, bisulfite sequencing, methylcytosine capture, sequencing, pyrosequencing), cell biology techniques (tissue culture, gene expression, gene silencing, cell imaging) and excellent computing skills (knowledge of databases, design of primers and processing of sequencing results). Candidates with additional background in bioinformatics would be highly regarded.


Selection criteria:
Essential criteria
PhD in biochemistry, molecular biology, cell biology or related science
Expertise and experience in nucleic acids related techniques and tissue culture
Expertise in any of the following: bisulfite sequencing, generation of miRNA libraries, sequencing, gene transfer or silencing, confocal microscopy
Excellent computing skills related to the processing of sequencing data
Proven track record in nucleic acid research, chromatin structure or regulation of transcription
Excellent written and oral communication skills
Demonstrated capacity for effective team work

Desirable criteria
Previous background in bioinformatics
Knowledge in mammalian physiology and metabolic diseases

Relationships:
The post holders will report to the Leader of the Environmental Epigenetics Group (Romain Barres), the Head of the Integrative Physiology Section (Juleen Zierath) and the Managing Director of CBMR (Anne Stæhr Johansen).
The post holders are expected to interact with staff at all levels, both internally and externally, regarding relevant research topics.

Highly motivated and ambitious candidates are encouraged to apply. Solid experience and an excellent track record gained in leading laboratories in the research field will be considered a distinct advantage. In all cases, ability to perform the job will be the primary consideration, and thus we encourage all - regardless of their personal background and status - to apply.

You can read more about the Center for Basic Metabolic Research on: http://metabol.ku.dk.

Deadline: 03-01-2011

For further information, please contact Group Leader Romain Barres, email: barres@sund.ku.dk.

Your application marked "211-0004/10-3860" including a CV and list of publications must be sent as one document to NNF Center for Basic Metabolic Research before January the 3rd, 2011. Your application should be sent by e-mail to metaboljobs@cbmr.ku.dk.


Please kindly mention Scholarization.blogspot.com when applying for this scholarship


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Scholarship Team: Ph.D Scholar Krisstofferson Joniel Scholarship Adviser, PhD Scholar Chea Vitom Scholarship Adviser and Senior Lecturer, PhD Scholar Rebecca T. Dalisay Scholarship Adviser, Ph.D Student Jiao Wang Scholarship Coordinator, MSc Student Dennise Maricel Scholarship Coordinator