Overview
The Paul Scherrer Institute is with 1300 employees the largest research centre for the natural and engineering sciences in Switzerland and a worldwide leading user laboratory. Its research activities are concentrated on the three main topics of solid-state physics, energy and environmental research as well as human health.
The Swiss Light Source (SLS) is one of the most advanced radiation sources worldwide. The SLS Macromolecular Crystallography Group operates two high performance undulator beamlines as well as a state-of-the-art bending magnet beamline for protein crystallography. The group is involved in several aspects of protein crystallography including beamline automation, crystallographic methods development as well as structural biology projects. We are looking for a
PhD Student in crystallography
Your tasks
The purpose of this PhD project is to develop new methods for the determination of nucleic acid (DNA/RNA) and nucleic acid/protein complex crystal structures and to later apply the developed tools to solve important and challenging structures.
The work will be done at the Swiss Light Source and will highly benefit of the latest instrumentation developments at the macromolecular crystallography beamlines (among them are the crystallization facility with in situ diffraction screening capabilities, the novel hybrid-pixel X-ray detector and a new multi-axes goniometer) as well as of the proximity to the Laboratory of Biomolecular Research.
The methodological development in crystallography will be done in collaboration with Dr Philippe Dumas at the University of Strasbourg, France and the biochemical work will be done in collaboration with Prof. Dr Roland Sigel at the University of Zürich, Switzerland. In this context, you will work on the improvement of data collection protocols and structure solution procedures as well as on the purification of large RNA molecules and crystallization.
This thesis project covers a wide range of techniques from biochemistry to crystallography techniques and therefore represents a good oportunity for a student with a strong interest in structural biology.
Your profile
You hold a diploma in biology, biochemistry or physicis and have a strong interest in structural biology. You are used to work in a team and have good communication skills in English. Knowledge in crystallography and X-rays diffraction are an asset.
Visit the following web pages:
http://sls.web.psi.ch/view.php/beamlines/px3/index.html
http://www-ibmc.u-strasbg.fr/arn/Dumas/index_dum_en.html
http://www.aci.uzh.ch/rna/
For further information please contact: Dr Vincent Olieric, phone +41 56 310 52 33 , vincent.olieric@psi.ch or Dr Meitian Wang, phone +41 56 310 41 75, meitian.wang@psi.ch
Please submit your application including CV quoting the ref. code by e-mail to miriam.zehnder@psi.ch or to Paul Scherrer Institut, Human Resources, ref. code 6112-02, Miriam Zehnder, 5232 Villigen PSI, Switzerland.
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
The Paul Scherrer Institute is with 1300 employees the largest research centre for the natural and engineering sciences in Switzerland and a worldwide leading user laboratory. Its research activities are concentrated on the three main topics of solid-state physics, energy and environmental research as well as human health.
The Swiss Light Source (SLS) is one of the most advanced radiation sources worldwide. The SLS Macromolecular Crystallography Group operates two high performance undulator beamlines as well as a state-of-the-art bending magnet beamline for protein crystallography. The group is involved in several aspects of protein crystallography including beamline automation, crystallographic methods development as well as structural biology projects. We are looking for a
PhD Student in crystallography
Your tasks
The purpose of this PhD project is to develop new methods for the determination of nucleic acid (DNA/RNA) and nucleic acid/protein complex crystal structures and to later apply the developed tools to solve important and challenging structures.
The work will be done at the Swiss Light Source and will highly benefit of the latest instrumentation developments at the macromolecular crystallography beamlines (among them are the crystallization facility with in situ diffraction screening capabilities, the novel hybrid-pixel X-ray detector and a new multi-axes goniometer) as well as of the proximity to the Laboratory of Biomolecular Research.
The methodological development in crystallography will be done in collaboration with Dr Philippe Dumas at the University of Strasbourg, France and the biochemical work will be done in collaboration with Prof. Dr Roland Sigel at the University of Zürich, Switzerland. In this context, you will work on the improvement of data collection protocols and structure solution procedures as well as on the purification of large RNA molecules and crystallization.
This thesis project covers a wide range of techniques from biochemistry to crystallography techniques and therefore represents a good oportunity for a student with a strong interest in structural biology.
Your profile
You hold a diploma in biology, biochemistry or physicis and have a strong interest in structural biology. You are used to work in a team and have good communication skills in English. Knowledge in crystallography and X-rays diffraction are an asset.
Visit the following web pages:
http://sls.web.psi.ch/view.php/beamlines/px3/index.html
http://www-ibmc.u-strasbg.fr/arn/Dumas/index_dum_en.html
http://www.aci.uzh.ch/rna/
For further information please contact: Dr Vincent Olieric, phone +41 56 310 52 33 , vincent.olieric@psi.ch or Dr Meitian Wang, phone +41 56 310 41 75, meitian.wang@psi.ch
Please submit your application including CV quoting the ref. code by e-mail to miriam.zehnder@psi.ch or to Paul Scherrer Institut, Human Resources, ref. code 6112-02, Miriam Zehnder, 5232 Villigen PSI, Switzerland.
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
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