Overview
A novel PhD Program "Regenerative Sciences" started in October 2007. This programme is designed and implemented by the Cluster of Excellence "From Regenerative Biology to Reconstructive Therapy" REBIRTH. This PhD study course is designed for students with an M.Sc. or equivalent diploma in Medicine, Veterinary Medicine, Biology, Biochemistry, Biotechnology, Molecular Biology, Chemistry or Physics. Engineers (e.g. Bioengineering) are welcome to apply as well.
The PhD program “Regenerative sciences” involves the partners of REBIRTH.
The 3-years curriculum is interdisciplinary and covers the following subjects:
Developmental biology: Principles of vertebrate and non-vertebrate development, embryogenesis and foetal period (focus on inner organs); genetic and epigenetic principles of development; model organisms; transgenic models (gain of function and loss of function); tissue specific transgenesis.
Stem cell biology: stem cell definition and classification (embryonic, foetal, germ cells, adult); normal and malignant stem cells; signal biology of self-renewal and differentiation (focus on heart, lung, liver, blood); stem cell purification and culture; genetic modification of stem cells (transient, semipermanent, stable); homing, migration and engraftment.
Ageing and degeneration: telomere biology, oxidative stress, somatic mutations; physical stress; inflammation; cancer; genetic determinants of life expectancy in model organisms; stem cell biology in aged organisms.
Inflammation: acute and chronic inflammation; inflammation and organ repair; inflammatory signals and (stem) cell biology; fibrosis.
Tumour biology: mechanisms of tumourigenesis; oncogenes and tumour suppressor genes; complementary mutations; loss of heterozygosity; induction and promotion; genetic and epigenetic stability, tumour immunity.
Transplantation (focus on heart, lung, liver, blood): rationale and need; organ availability; strategies (autologous, allogeneic, xenogeneic); transplant immunology (host versus graft and graft versus host); prosthetics; supportive care.
Materials sciences: biomaterials in medicine; classes of materials; materials engineering and functionalisation; biocompatibility; integration.
Growth factors and their receptors: regulation of cell survival, migration and apoptosis by ligands; soluble versus membrane-bound principles; gradients; clinical use of growth factors.
Cell therapy: forms and applications; cell sources; cell purification and processing; cell modification (genetic, epigenetic, via DNA, RNA, proteins and chemicals).Tissue engineering: principles and practice; the interdisciplinary basis of tissue engineering; integrating materials sciences and cell biology; quality and quantity issues; process development.
Process development and Good Practice: The three forms of Good Practice: clinical (GCP), manufacturing (GMP) and laboratory (GLP); rules and regulations; standard operating procedures (design, conduct, documentation); quality control; audits and reporting; upscaling and tuning of processes.
Risk assessment: biodistribution; horizontal and vertical transmission; complications of regenerative agents; complications of cell therapy and tissue engineering; proactive pharmacovigilance; design of preclinical models.
Clinical trials: design and conduct, informed consent contents and language, insurance.Regulatory and industry interactions: from basic research over process development to clinical trials; integrative and proactive communication with regulatory boards and industry.
Societal relations and ethical issues: principles of research ethics; history of regenerative medicine; “therapeutic” and reproductive cloning; cultural differences; health and economy and further societal issues; dialogue with patient organisations and the public.
Practical courses: These will be organised by REBIRTH’s service units or other key laboratories.
Chairman
Coordination
Prof. Dr. C. Baum
Experimental Hematology&Oncology
Tel.: +49-511-532-6067
Fax: +49-511-532-6068
Email: baum.christophermh-hannover.de
Carl-Neuberg-Str. 1
D-30625 Hannover
Dr. Daniela Pelz
Tel.: +49-511-532-5206
Fax: +49-511-532-5404
E-mail: pelz.danielamh-hannover.de
Further information about this program can be found at: http://www.mh-hannover.de/2823.html#c5324
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
A novel PhD Program "Regenerative Sciences" started in October 2007. This programme is designed and implemented by the Cluster of Excellence "From Regenerative Biology to Reconstructive Therapy" REBIRTH. This PhD study course is designed for students with an M.Sc. or equivalent diploma in Medicine, Veterinary Medicine, Biology, Biochemistry, Biotechnology, Molecular Biology, Chemistry or Physics. Engineers (e.g. Bioengineering) are welcome to apply as well.
The PhD program “Regenerative sciences” involves the partners of REBIRTH.
The 3-years curriculum is interdisciplinary and covers the following subjects:
Developmental biology: Principles of vertebrate and non-vertebrate development, embryogenesis and foetal period (focus on inner organs); genetic and epigenetic principles of development; model organisms; transgenic models (gain of function and loss of function); tissue specific transgenesis.
Stem cell biology: stem cell definition and classification (embryonic, foetal, germ cells, adult); normal and malignant stem cells; signal biology of self-renewal and differentiation (focus on heart, lung, liver, blood); stem cell purification and culture; genetic modification of stem cells (transient, semipermanent, stable); homing, migration and engraftment.
Ageing and degeneration: telomere biology, oxidative stress, somatic mutations; physical stress; inflammation; cancer; genetic determinants of life expectancy in model organisms; stem cell biology in aged organisms.
Inflammation: acute and chronic inflammation; inflammation and organ repair; inflammatory signals and (stem) cell biology; fibrosis.
Tumour biology: mechanisms of tumourigenesis; oncogenes and tumour suppressor genes; complementary mutations; loss of heterozygosity; induction and promotion; genetic and epigenetic stability, tumour immunity.
Transplantation (focus on heart, lung, liver, blood): rationale and need; organ availability; strategies (autologous, allogeneic, xenogeneic); transplant immunology (host versus graft and graft versus host); prosthetics; supportive care.
Materials sciences: biomaterials in medicine; classes of materials; materials engineering and functionalisation; biocompatibility; integration.
Growth factors and their receptors: regulation of cell survival, migration and apoptosis by ligands; soluble versus membrane-bound principles; gradients; clinical use of growth factors.
Cell therapy: forms and applications; cell sources; cell purification and processing; cell modification (genetic, epigenetic, via DNA, RNA, proteins and chemicals).Tissue engineering: principles and practice; the interdisciplinary basis of tissue engineering; integrating materials sciences and cell biology; quality and quantity issues; process development.
Process development and Good Practice: The three forms of Good Practice: clinical (GCP), manufacturing (GMP) and laboratory (GLP); rules and regulations; standard operating procedures (design, conduct, documentation); quality control; audits and reporting; upscaling and tuning of processes.
Risk assessment: biodistribution; horizontal and vertical transmission; complications of regenerative agents; complications of cell therapy and tissue engineering; proactive pharmacovigilance; design of preclinical models.
Clinical trials: design and conduct, informed consent contents and language, insurance.Regulatory and industry interactions: from basic research over process development to clinical trials; integrative and proactive communication with regulatory boards and industry.
Societal relations and ethical issues: principles of research ethics; history of regenerative medicine; “therapeutic” and reproductive cloning; cultural differences; health and economy and further societal issues; dialogue with patient organisations and the public.
Practical courses: These will be organised by REBIRTH’s service units or other key laboratories.
Chairman
Coordination
Prof. Dr. C. Baum
Experimental Hematology&Oncology
Tel.: +49-511-532-6067
Fax: +49-511-532-6068
Email: baum.christophermh-hannover.de
Carl-Neuberg-Str. 1
D-30625 Hannover
Dr. Daniela Pelz
Tel.: +49-511-532-5206
Fax: +49-511-532-5404
E-mail: pelz.danielamh-hannover.de
Further information about this program can be found at: http://www.mh-hannover.de/2823.html#c5324
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
0 comments:
Post a Comment