Overview
Supervisors: Dr Matthew Wright, Dr Fiona Oakley, Professor Derek Mann
Institute: Institute of Cellular Medicine
Sponsor: NC3Rs
Duration of the award: 4 years (MRes Medical and Molecular Biosciences followed by a three-year PhD)
Liver disease is a major cause of mortality and morbidity and it is predicted to rise in the future. Considerable effort will be needed to find effective treatments and the use of animal models is essential because the fibrosis (scarring) process is dependent on multiple cell types within the liver and on tissues outwith the liver. A major aim of this project however, will be to refine the use of animal models and hence reduce the number of animals used in studies.
The project will have two major themes:
i) to examine the potential of the periportal hepatotoxin drug methapyrilene, as a replacement for bile duct ligation (currently used in the model of cholestatic liver disease)
ii) to examine the use of an antibody to image fibrosis severity using IVIS in various animal models of liver disease.
The successful applicant will take a module about applying 'the 3R's' (reduction, refinement, replacement) to in vivo experimental techniques. Additionally the student will attend Home Office modules and will be educated in the ethical considerations of animal research.
The student will employ a range of in vitro techniques to test the quality of antibody preparations and pre-in vivo testing in tissue culture prior to use in animal studies. The project will therefore give the successful applicant an excellent introduction to in vitro and in vivo techniques, drug-induced liver injury and chronic liver disease, fields of major interest to the pharmaceutical industry and clinicians. The successful applicant will also be working in a research grouping that has a prominent international profile in liver fibrosis research.
Project start date: September 2010
Eligibility and Value of the Award
The MRC's student eligibility criteria apply to this funding. Depending on how you meet the criteria, you may receive a full or partial award. A full award covers tuition fees and an annual stipend of £13,650 (20010/11). A partial award covers fees only.
Person Specification
You should have, or expect to achieve, a first-class or upper-second-class Honours degree, in a relevant subject.
How to Apply
The University's postgraduate application form must be completed; selecting 'Master of Research/Doctor of Philosophy - Medical Sciences (Cellular Medicine)'as the programme of study and inserting the reference number ICM93. Only mandatory fields need to be completed (no personal statement required) - a CV and covering letter must be attached. The covering letter must state the title of the studentship, quote the reference number ICM93 and state how your interests and experience relate to the project.
Closing date for applications: early application is advised as applications will only be considered until a suitable candidate is found.
Further Information
For more details, please contact Dr Matthew Wright, m.c.wright@ncl.ac.uk, 0191 222 7094 0191 222 7094
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
Supervisors: Dr Matthew Wright, Dr Fiona Oakley, Professor Derek Mann
Institute: Institute of Cellular Medicine
Sponsor: NC3Rs
Duration of the award: 4 years (MRes Medical and Molecular Biosciences followed by a three-year PhD)
Liver disease is a major cause of mortality and morbidity and it is predicted to rise in the future. Considerable effort will be needed to find effective treatments and the use of animal models is essential because the fibrosis (scarring) process is dependent on multiple cell types within the liver and on tissues outwith the liver. A major aim of this project however, will be to refine the use of animal models and hence reduce the number of animals used in studies.
The project will have two major themes:
i) to examine the potential of the periportal hepatotoxin drug methapyrilene, as a replacement for bile duct ligation (currently used in the model of cholestatic liver disease)
ii) to examine the use of an antibody to image fibrosis severity using IVIS in various animal models of liver disease.
The successful applicant will take a module about applying 'the 3R's' (reduction, refinement, replacement) to in vivo experimental techniques. Additionally the student will attend Home Office modules and will be educated in the ethical considerations of animal research.
The student will employ a range of in vitro techniques to test the quality of antibody preparations and pre-in vivo testing in tissue culture prior to use in animal studies. The project will therefore give the successful applicant an excellent introduction to in vitro and in vivo techniques, drug-induced liver injury and chronic liver disease, fields of major interest to the pharmaceutical industry and clinicians. The successful applicant will also be working in a research grouping that has a prominent international profile in liver fibrosis research.
Project start date: September 2010
Eligibility and Value of the Award
The MRC's student eligibility criteria apply to this funding. Depending on how you meet the criteria, you may receive a full or partial award. A full award covers tuition fees and an annual stipend of £13,650 (20010/11). A partial award covers fees only.
Person Specification
You should have, or expect to achieve, a first-class or upper-second-class Honours degree, in a relevant subject.
How to Apply
The University's postgraduate application form must be completed; selecting 'Master of Research/Doctor of Philosophy - Medical Sciences (Cellular Medicine)'as the programme of study and inserting the reference number ICM93. Only mandatory fields need to be completed (no personal statement required) - a CV and covering letter must be attached. The covering letter must state the title of the studentship, quote the reference number ICM93 and state how your interests and experience relate to the project.
Closing date for applications: early application is advised as applications will only be considered until a suitable candidate is found.
Further Information
For more details, please contact Dr Matthew Wright, m.c.wright@ncl.ac.uk, 0191 222 7094 0191 222 7094
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
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