Overview
We are searching for a PhD student for work within the international research project “Tumor-targeting of Therapeutic Oligonucleotides with DARPins“ starting September 1st, 2010.
The transdisciplinary project is aimed at the optimization of a nanosystem for targeted delivery of antisense and siRNA oligonucleotides to tumors. During the PhD work, ankyrin repeat proteins will be modified to allow complexation or covalent conjugation of oligonucleotides. The resulting nanomedicines will be subsequently tested in cell culture models. Additionally, the chemical synthesis and design of antisense and siRNA oligonucleotides for gene silencing of promising cancer targets is an objective of the PhD thesis.
Techniques relevant to the work comprise automated oligonucleotide synthesis, molecular cloning, recombinant protein expression, qPCR, western blot, and cell biological assays.
Target candidates
We are looking for a self-motivated graduate student of pharmacy, bioorganic chemistry, biochemistry, molecular biology or a related field with an innovative and flexible mindset. Prior experience in oligonucleotide synthesis, protein biochemistry, or in vitro gene silencing is desirable.
Vienna offers high quality of life in a formidable cultural setting together with numerous possibilities for outdoor and indoor activities.
Inquiries and application
Send questions and applications including CV and contact details of two referees to:
Dr. Johannes Winkler
Department of Medicinal Chemistry
Althanstrasse 14
1090 Vienna
Austria
Tel. +43 1 4277 55058
johannes.winkler@univie.ac.at
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
We are searching for a PhD student for work within the international research project “Tumor-targeting of Therapeutic Oligonucleotides with DARPins“ starting September 1st, 2010.
The transdisciplinary project is aimed at the optimization of a nanosystem for targeted delivery of antisense and siRNA oligonucleotides to tumors. During the PhD work, ankyrin repeat proteins will be modified to allow complexation or covalent conjugation of oligonucleotides. The resulting nanomedicines will be subsequently tested in cell culture models. Additionally, the chemical synthesis and design of antisense and siRNA oligonucleotides for gene silencing of promising cancer targets is an objective of the PhD thesis.
Techniques relevant to the work comprise automated oligonucleotide synthesis, molecular cloning, recombinant protein expression, qPCR, western blot, and cell biological assays.
Target candidates
We are looking for a self-motivated graduate student of pharmacy, bioorganic chemistry, biochemistry, molecular biology or a related field with an innovative and flexible mindset. Prior experience in oligonucleotide synthesis, protein biochemistry, or in vitro gene silencing is desirable.
Vienna offers high quality of life in a formidable cultural setting together with numerous possibilities for outdoor and indoor activities.
Inquiries and application
Send questions and applications including CV and contact details of two referees to:
Dr. Johannes Winkler
Department of Medicinal Chemistry
Althanstrasse 14
1090 Vienna
Austria
Tel. +43 1 4277 55058
johannes.winkler@univie.ac.at
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
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