Overview
We offer a 3 years position as Early Stage Researcher with the framework of the Marie Curie Initial Training Network Nucleosome4D. The PhD student will carry out a project aimed at reconstitution and structural analysis of silent chromatin from S. cerevisiae. We have successfully expressed and assembled SIR proteins on nucleosomal arrays and now seek to determine the structure by crystalization of subdomains and EM tomography of the entire nucleosome-repressor complex. The project requires the application of skills in biochemistry, molecular biology (tissue culture, basic biochemistry, nucleic acid detection) and willingness to be trained in EM tomography.
Program Description
As part of the Marie Curie Training Network 4D we offer a PhD fellowship to study the structure of silent chromatin reconstituted from recombinant repressor proteins and histones. The project will be pursued in collaboration with the protein structure facility at the FMI and the Center for Imaging and nanoanalytic analysis of the University of Basel. The successful applicant will come with basic skills in biochemistry and with good grasp of biophysical principles. The project will entail protein purification, protein-DNA binding studies and structure determination. Sir protein assembly has been published from the Gasser laboratory (see Martino et al.,Molecular Cell 2009). The project will be guided by a postdoc in the laboratory as well as the group leader.. Training in an array of career advancing skills (speaking, writing, presentations and computational biology) will be provided as part of the Marie Curie Training Network. More information on our website (www.fmi.ch/groups/gasser.s/web).
Nucleosome4D involves 14 organizations from different countries and will carry out multidisciplinary collaborative research projects focused on deciphering nucleosome structure and function across biological space and time (Nucleosome4D). Our main objective is to provide young researchers with world-class research & training in chromatin biology. We will use cutting-edge methods and collaborative projects to determine how nucleosomes are remodeled during transcription, when genes are silenced, as cell divide, as stem cells differentiate, during organismal development and in human disease. We utilize complementary approaches in structural biology, biophysics, cell biology, live-cell imaging, biochemistry, genetics, genomics and bioinformatics.
Research Field
Biological sciences - Biology
Benefits
maternity leave 18 weeks,
vacation days : 25
Application Deadline
30/07/2010
Friedrich Miescher Institute for Biomedical Research
Grant Management
Research Laboratory
Maulbeerstrasse 66
4058 - Basel
BS - SWITZERLAND
phone +41 61 6972982
fax +41 61 6973976
email dorothy.searles@fmi.ch
Please kindly mention Scholarization.blogspot.com when applying for this fellowship
We offer a 3 years position as Early Stage Researcher with the framework of the Marie Curie Initial Training Network Nucleosome4D. The PhD student will carry out a project aimed at reconstitution and structural analysis of silent chromatin from S. cerevisiae. We have successfully expressed and assembled SIR proteins on nucleosomal arrays and now seek to determine the structure by crystalization of subdomains and EM tomography of the entire nucleosome-repressor complex. The project requires the application of skills in biochemistry, molecular biology (tissue culture, basic biochemistry, nucleic acid detection) and willingness to be trained in EM tomography.
Program Description
As part of the Marie Curie Training Network 4D we offer a PhD fellowship to study the structure of silent chromatin reconstituted from recombinant repressor proteins and histones. The project will be pursued in collaboration with the protein structure facility at the FMI and the Center for Imaging and nanoanalytic analysis of the University of Basel. The successful applicant will come with basic skills in biochemistry and with good grasp of biophysical principles. The project will entail protein purification, protein-DNA binding studies and structure determination. Sir protein assembly has been published from the Gasser laboratory (see Martino et al.,Molecular Cell 2009). The project will be guided by a postdoc in the laboratory as well as the group leader.. Training in an array of career advancing skills (speaking, writing, presentations and computational biology) will be provided as part of the Marie Curie Training Network. More information on our website (www.fmi.ch/groups/gasser.s/web).
Nucleosome4D involves 14 organizations from different countries and will carry out multidisciplinary collaborative research projects focused on deciphering nucleosome structure and function across biological space and time (Nucleosome4D). Our main objective is to provide young researchers with world-class research & training in chromatin biology. We will use cutting-edge methods and collaborative projects to determine how nucleosomes are remodeled during transcription, when genes are silenced, as cell divide, as stem cells differentiate, during organismal development and in human disease. We utilize complementary approaches in structural biology, biophysics, cell biology, live-cell imaging, biochemistry, genetics, genomics and bioinformatics.
Research Field
Biological sciences - Biology
Benefits
maternity leave 18 weeks,
vacation days : 25
Application Deadline
30/07/2010
Friedrich Miescher Institute for Biomedical Research
Grant Management
Research Laboratory
Maulbeerstrasse 66
4058 - Basel
BS - SWITZERLAND
phone +41 61 6972982
fax +41 61 6973976
email dorothy.searles@fmi.ch
Please kindly mention Scholarization.blogspot.com when applying for this fellowship
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