Overview
Chronic obstructive pulmonary disease (COPD) is a common and disabling chronic health condition that is characterized by airflow obstruction, associated with chronic bronchitis and/or emphysema and an abnormal pulmonary inflammatory response. The increase in morbidity and mortality of COPD worldwide is largely driven by the female population. Insight in mechanisms underlying the increased susceptibility in females to smoke is therefore crucial to understand why female patients are more susceptible to develop COPD, and to develop novel therapeutic agents specifically aimed at the growing population of female COPD patients. Many leads suggest that the immune and endocrine systems contribute to the sexual dimorphism in the pathogenesis of COPD. In this project entitled “Smoking and femininity: hormonal cross-talk in the development of COPD?”, you will investigate gender aspects of smoke-induced pulmonary pathophysiology and the underlying molecular mechanisms involved.
You will focus on the functional role of the adipo-cytokine leptin, known to play an orchestrating role in pulmonary inflammatory responses, the female sex hormone estrogen and the synergism between leptin and estrogen signalling in smoke-induced lung pathophysiology. The project aims will be addressed by a unique mixture of in vitro mechanistic experiments in cell lines and primary cell cultures, experimental models for COPD combined with genetic and/or pharmaceutical interventions, and multiple analyses of human lung tissue. A broad range of molecular biological and immunological techniques will be used for analyses.
Description
Candidate should have a Master Degree in Biology, Molecular Life Sciences, Health Sciences, Medicine or a comparable degree with an interest in basic, translational research. Individuals with prior lab experience in cell culture, molecular biology and/or small animal models (Art.9 or 12) are encouraged to apply. You should display team spirit, perseverance, and good verbal and written communication skills in English
Research Fields
Medical sciences
Benefits
The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website http://www.maastrichtuniversity.nl/ , A-Z Terms of Employment. Temporary employment for 4 years. Your salary would be € 2.042,-- gross per month in the first year up to € 2.612,-- gross per month in the fourth year according to the PhD-student salary scale. Each year an evaluation will take place.
Maastricht University
NUTRIM School for Nutrition, Toxicology and Metabolism
P.O. Box 616
6200 MD - Maastricht
NETHERLANDS
email pzfdgvacatures@facburfdg.unimaas.nl
http://www.maastrichtuniversity.nl/
Application Deadline
09/08/2010
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
Chronic obstructive pulmonary disease (COPD) is a common and disabling chronic health condition that is characterized by airflow obstruction, associated with chronic bronchitis and/or emphysema and an abnormal pulmonary inflammatory response. The increase in morbidity and mortality of COPD worldwide is largely driven by the female population. Insight in mechanisms underlying the increased susceptibility in females to smoke is therefore crucial to understand why female patients are more susceptible to develop COPD, and to develop novel therapeutic agents specifically aimed at the growing population of female COPD patients. Many leads suggest that the immune and endocrine systems contribute to the sexual dimorphism in the pathogenesis of COPD. In this project entitled “Smoking and femininity: hormonal cross-talk in the development of COPD?”, you will investigate gender aspects of smoke-induced pulmonary pathophysiology and the underlying molecular mechanisms involved.
You will focus on the functional role of the adipo-cytokine leptin, known to play an orchestrating role in pulmonary inflammatory responses, the female sex hormone estrogen and the synergism between leptin and estrogen signalling in smoke-induced lung pathophysiology. The project aims will be addressed by a unique mixture of in vitro mechanistic experiments in cell lines and primary cell cultures, experimental models for COPD combined with genetic and/or pharmaceutical interventions, and multiple analyses of human lung tissue. A broad range of molecular biological and immunological techniques will be used for analyses.
Description
Candidate should have a Master Degree in Biology, Molecular Life Sciences, Health Sciences, Medicine or a comparable degree with an interest in basic, translational research. Individuals with prior lab experience in cell culture, molecular biology and/or small animal models (Art.9 or 12) are encouraged to apply. You should display team spirit, perseverance, and good verbal and written communication skills in English
Research Fields
Medical sciences
Benefits
The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply. For more information look at the website http://www.maastrichtuniversity.nl/ , A-Z Terms of Employment. Temporary employment for 4 years. Your salary would be € 2.042,-- gross per month in the first year up to € 2.612,-- gross per month in the fourth year according to the PhD-student salary scale. Each year an evaluation will take place.
Maastricht University
NUTRIM School for Nutrition, Toxicology and Metabolism
P.O. Box 616
6200 MD - Maastricht
NETHERLANDS
email pzfdgvacatures@facburfdg.unimaas.nl
http://www.maastrichtuniversity.nl/
Application Deadline
09/08/2010
Please kindly mention Scholarization.blogspot.com when applying for this opportunity
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